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Literature summary for 1.14.19.44 extracted from

  • Tripodi, K.E.; Buttigliero, L.V.; Altabe, S.G.; Uttaro, A.D.
    Functional characterization of front-end desaturases from trypanosomatids depicts the first polyunsaturated fatty acid biosynthetic pathway from a parasitic protozoan (2006), FEBS J., 273, 271-280.
    View publication on PubMed
Search for more literature for 1.14.19.44

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain HH3 Leishmania major

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+ Leishmania major
-
 arachidonoyl-CoA + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+ Leishmania major Friedlin
-
 arachidonoyl-CoA + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+ Leishmania major
-
 (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+ Leishmania major Friedlin
-
 (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-
Leishmania major Friedlin
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Leishmania major arachidonoyl-CoA + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Leishmania major Friedlin arachidonoyl-CoA + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Leishmania major (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
 ?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Leishmania major Friedlin (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Synonyms

Synonyms Comment Organism
DELTA 5-desaturase
-
 Leishmania major
FADDELTA5
-
 Leishmania major

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Leishmania major