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Literature summary for 1.14.99.1 extracted from
- Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs (1997), Mol. Pharmacol., 51, 52-60.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | study of aspirin acetylated enzyme in order to inhibit prostaglandin synthesis | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S516M | mutation mimics acetylation of Ser516, mutant still sensitive to most inhibitors, not: diclofenac, meclofenamic acid | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
recombinant enzyme, product of COX-2 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonic acid + AH2 + 2 O2 | - |
Homo sapiens | 15(R)-hydroxy-eicosatetraenoic acid + A + H2O | product of aspirin acetylated enzyme or S516M mutant | ? |  |
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Release 2023.1 (January 2023)
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