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Literature summary for 1.14.99.1 extracted from

  • Zhang, D.; Wood, C.E.
    Neuronal prostaglandin endoperoxide synthase 2 responses to oxygen and glucose deprivation are mediated by mitogen-activated protein kinase ERK1/2 (2005), Brain Res., 1060, 100-107.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information hypoxia and glucose-free medium treatment synergistically increase PGHS-2 mRNA approximately 8fold Homo sapiens
additional information oxygen and glucose depivation induce PGHS-2 gene expression synergistically in neurons Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PD-98059 MEK inhibitor, blocks specifically the activation of ERK1/2 and the PGHS-2 mRNA response to oxygen and glucose depivation, hence ERK is a mediator of PGHS-2 gene expression Homo sapiens
SB203580 inhibitor of p38, reduces the PGHS-2 response to oxygen and glucose depivation by approximately 50% Homo sapiens
U0126 MEK inhibitor, blocks specifically the activation of ERK1/2 and the PGHS-2 mRNA response to oxygen and glucose depivation, hence ERK is a mediator of PGHS-2 gene expression Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
estimated by PAGE and Western blotting Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + AH2 + O2 Homo sapiens
-
prostaglandin H2 + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35354
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SK-N-AS cell human neuroblastoma cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + AH2 + O2
-
Homo sapiens prostaglandin H2 + A + H2O
-
?

Synonyms

Synonyms Comment Organism
PGHS-2
-
Homo sapiens
prostaglandin endoperoxide synthase 2
-
Homo sapiens