Application | Comment | Organism |
---|---|---|
medicine | amphetamines, bioactivated by prostaglandin H synthase, cause reactive oxygen species formation, implicated in amphetamine-initiated neurodegeneration | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Acetylsalicylic acid | - |
Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
immunoblot | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | Mus musculus | - |
prostaglandin H2 + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex | - |
Mus musculus | - |
brain stem | - |
Mus musculus | - |
cerebellum | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
striatum | - |
Mus musculus | - |
substantia nigra | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | - |
Mus musculus | prostaglandin H2 + A + H2O | - |
? | |
arachidonic acid + 3,4-methylenedioxyamphetamine | postulated bioactivation to a neurodegenerative free radical intermediate that can initiate the formation of reactive oxygen species | Mus musculus | ? | - |
? | |
arachidonic acid + 3,4-methylenedioxymethamphetamine | postulated bioactivation to a neurodegenerative free radical intermediate that can initiate the formation of reactive oxygen species | Mus musculus | ? | - |
? | |
arachidonic acid + methamphetamine | postulated bioactivation to a neurodegenerative free radical intermediate that can initiate the formation of reactive oxygen species | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PHS | - |
Mus musculus |
PHS-1 | - |
Mus musculus |
prostaglandin H synthase | - |
Mus musculus |