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Literature summary for 1.14.99.1 extracted from

  • Gersting, J.; Schaub, C.E.; Keller-Wood, M.; Wood, C.E.
    Inhibition of brain prostaglandin endoperoxide synthase-2 prevents the preparturient increase in fetal adrenocorticotropin secretion in the sheep fetus (2008), Endocrinology, 149, 4128-4136.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information nimesulide inhibits PGHS-2 turnover in most brain regions Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Ovis aries prostaglandin synthesis within the fetal central nervous system is critical for the the modulation of hypotension-induced fetal ACTH secretion involving PGHS-2, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Ovis aries P05979 PGHS-1
-
Ovis aries P79208 PGHS-2
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland fetal Ovis aries
-
brain
-
Ovis aries
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brain stem
-
Ovis aries
-
cerebellum
-
Ovis aries
-
cerebral cortex
-
Ovis aries
-
hippocampus
-
Ovis aries
-
hypothalamus fetal Ovis aries
-
additional information relationship of PGHS-2 and PGHS-1 mRNA and activity in brain tissues, overview Ovis aries
-
pituitary gland fetal Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information prostaglandin synthesis within the fetal central nervous system is critical for the the modulation of hypotension-induced fetal ACTH secretion involving PGHS-2, overview Ovis aries ?
-
?

Synonyms

Synonyms Comment Organism
PGHS-1
-
Ovis aries
PGHS-2
-
Ovis aries
prostaglandin endoperoxide synthase-1
-
Ovis aries
prostaglandin endoperoxide synthase-2
-
Ovis aries