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Literature summary for 1.14.99.1 extracted from

  • Lee, C.J.; Goncalves, L.L.; Wells, P.G.
    Embryopathic effects of thalidomide and its hydrolysis products in rabbit embryo culture: evidence for a prostaglandin H synthase (PHS)-dependent, reactive oxygen species (ROS)-mediated mechanism (2011), FASEB J., 25, 2468-2483.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5,8,11,14-Eicosatetraynoic acid
-
Oryctolagus cuniculus
Acetylsalicylic acid irreversible inhibitor Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
isozymes PHS-1 and PHS-2
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
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Oryctolagus cuniculus
-

Synonyms

Synonyms Comment Organism
PHS
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Oryctolagus cuniculus
prostaglandin H synthase
-
Oryctolagus cuniculus

General Information

General Information Comment Organism
additional information PHS is involved in the mechanism of thalidomide to cause increased embryonic DNA oxidation measured as 8-oxoguanine leading to embryopathies, phenotype, overview. A prostaglandin H synthase-dependent, reactive oxygen species-mediated mechanism. Thalidomide teratogenicity was blocked by maternal pretreatment with acetylsalicylic acid, an irreversible inhibitor of prostaglandin H synthase Oryctolagus cuniculus