Literature summary for 1.14.99.15 extracted from

Furuya, T.; Kino, K.
Regioselective oxidation of indole- and quinolinecarboxylic acids by cytochrome P450 CYP199A2 (2010), Appl. Microbiol. Biotechnol., 85, 1861-1868.

Search for more literature for 1.14.99.15

Application

Application	Comment	Organism
synthesis	CYP199A2 may be a valuable biocatalyst for the regioselective oxidation of various aromatic carboxylic acids	Rhodopseudomonas palustris

Cloned(Commentary)

Cloned (Comment)	Organism
CYP199A2 gene RPA1871, coexpression with palustris redoxin gene from Rhodopseudomonas palustris and putidaredoxin reductase gene from Pseudomonas putida to provide the redox partners of CYP199A2 in Escherichia coli	Rhodopseudomonas palustris

Organism

Organism	UniProt	Comment	Textmining
Rhodopseudomonas palustris	-	gene RPA1871	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme performs regioselective oxidation of indole- and quinolinecarboxylic acids, it oxidizes 2-naphthoic acid and 4-ethylbenzoic acid, substrate specificity and regioselectivity of CYP199A2, overview. CYP199A2 does not exhibit any activity towards indole and indole-3-carboxylic acid, whereas this enzyme oxidizes indole-2-carboxylic acid, indole-5-carboxylic acid, and indole-6-carboxylic acid. Indole-2-carboxylic acid is converted to 5- and 6-hydroxyindole-2-carboxylic acids at a ratio of 59:41. In contrast, the indole-6-carboxylic acid oxidation generates only one product, 2-indolinone-6-carboxylic acid. The oxidation product of quinoline-6-carboxylic acid is 3-hydroxyquinoline-6-carboxylic acid	Rhodopseudomonas palustris	?	-	?

Synonyms

Synonyms	Comment	Organism
CYP199A2	-	Rhodopseudomonas palustris
cytochrome P450 199A2	-	Rhodopseudomonas palustris

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Release 2023.1 (January 2023)