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Literature summary for 1.14.99.22 extracted from

  • Keogh, D.P.; Mitchell, M.J.; Crooks, J.R.; Smith, S.L.
    Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity (1991), Experientia, 48, 39-41.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,9-Dideoxyforskolin dose dependent inhibition Drosophila melanogaster
1,9-Dideoxyforskolin dose dependent inhibition Manduca sexta
7-O-Hemisuccinyl-7-deacetyl-forskolin
-
Drosophila melanogaster
7-O-Hemisuccinyl-7-deacetyl-forskolin
-
Manduca sexta
forskolin 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-dihydroxylabd-14-en-11-one, adenylate cyclase activator Drosophila melanogaster
forskolin 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-dihydroxylabd-14-en-11-one, adenylate cyclase activator Manduca sexta

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ecdysone + NADPH + O2 Drosophila melanogaster serves as precursor of ecdysterone, the active moulting hormone in larval insects 20-hydroxyecdysone + NADP+ + H2O
-
?
ecdysone + NADPH + O2 Manduca sexta serves as precursor of ecdysterone, the active moulting hormone in larval insects 20-hydroxyecdysone + NADP+ + H2O
-
?
ecdysone + NADPH + O2 Drosophila melanogaster Canton S serves as precursor of ecdysterone, the active moulting hormone in larval insects 20-hydroxyecdysone + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
canton S strain
-
Drosophila melanogaster Canton S
-
canton S strain
-
Manduca sexta
-
tobacco hornworm
-

Reaction

Reaction Comment Organism Reaction ID
ecdysone + reduced acceptor + O2 = 20-hydroxyecdysone + acceptor + H2O NADPH-dependent monooxygenase containing cytochrome P-450, a heme-thiolate protein Drosophila melanogaster
ecdysone + reduced acceptor + O2 = 20-hydroxyecdysone + acceptor + H2O NADPH-dependent monooxygenase containing cytochrome P-450, a heme-thiolate protein Manduca sexta

Source Tissue

Source Tissue Comment Organism Textmining
fat body larval Drosophila melanogaster
-
fat body larval Manduca sexta
-
midgut
-
Manduca sexta
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00000433
-
-
Drosophila melanogaster
0.0000197
-
fat body Manduca sexta
0.0001721
-
midgut Manduca sexta

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-ecdysone + NADPH + O2
-
Drosophila melanogaster 20-hydroxyecdysone + NADP+ + H2O
-
?
alpha-ecdysone + NADPH + O2
-
Manduca sexta 20-hydroxyecdysone + NADP+ + H2O
-
?
alpha-ecdysone + NADPH + O2
-
Drosophila melanogaster Canton S 20-hydroxyecdysone + NADP+ + H2O
-
?
ecdysone + NADPH + O2 serves as precursor of ecdysterone, the active moulting hormone in larval insects Drosophila melanogaster 20-hydroxyecdysone + NADP+ + H2O
-
?
ecdysone + NADPH + O2 serves as precursor of ecdysterone, the active moulting hormone in larval insects Manduca sexta 20-hydroxyecdysone + NADP+ + H2O
-
?
ecdysone + NADPH + O2 serves as precursor of ecdysterone, the active moulting hormone in larval insects Drosophila melanogaster Canton S 20-hydroxyecdysone + NADP+ + H2O
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Drosophila melanogaster
6.5
-
-
Manduca sexta

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 essential Drosophila melanogaster
cytochrome P450 essential Manduca sexta
NADPH
-
Drosophila melanogaster
NADPH
-
Manduca sexta