Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-isopropoxy-1,4-naphthoquinone | synthetic compound | Aedes aegypti | |
2-isopropoxy-1,4-naphthoquinone | synthetic compound | Drosophila melanogaster | |
2-isopropoxy-1,4-naphthoquinone | synthetic compound | Manduca sexta | |
2-methoxy-1,4-naphthoquinone | isolated from the leaves of Impatiens glandulifera | Aedes aegypti | |
2-methoxy-1,4-naphthoquinone | isolated from the leaves of Impatiens glandulifera | Drosophila melanogaster | |
2-methoxy-1,4-naphthoquinone | isolated from the leaves of Impatiens glandulifera | Manduca sexta | |
2-propoxy-1,4-naphthoquinone | synthetic compound | Aedes aegypti | |
2-propoxy-1,4-naphthoquinone | synthetic compound | Drosophila melanogaster | |
2-propoxy-1,4-naphthoquinone | synthetic compound | Manduca sexta | |
additional information | inhibition profiles | Aedes aegypti | |
additional information | inhibition profiles | Drosophila melanogaster | |
additional information | inhibition profiles | Manduca sexta |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | a cytochrome P450-dependent hydroxylase | Drosophila melanogaster | |
Fe2+ | a cytochrome P450-dependent hydroxylase | Aedes aegypti | |
Fe2+ | a cytochrome P450-dependent hydroxylase | Manduca sexta |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ecdysone + AH2 + O2 | Drosophila melanogaster | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | 20-hydroxyecdysone + A + H2O | - |
? | |
ecdysone + AH2 + O2 | Aedes aegypti | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | 20-hydroxyecdysone + A + H2O | - |
? | |
ecdysone + AH2 + O2 | Manduca sexta | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | 20-hydroxyecdysone + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aedes aegypti | - |
females | - |
Drosophila melanogaster | - |
- |
- |
Manduca sexta | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
abdomen | - |
Aedes aegypti | - |
fat body | from fifth instar larvae | Manduca sexta | - |
larva | fifth instar larvae | Manduca sexta | - |
larva | wandering stage third instar larvae | Drosophila melanogaster | - |
midgut | from fifth instar larvae | Manduca sexta | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Drosophila melanogaster |
additional information | - |
- |
Aedes aegypti |
additional information | - |
- |
Manduca sexta |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ecdysone + AH2 + O2 | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | Drosophila melanogaster | 20-hydroxyecdysone + A + H2O | - |
? | |
ecdysone + AH2 + O2 | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | Aedes aegypti | 20-hydroxyecdysone + A + H2O | - |
? | |
ecdysone + AH2 + O2 | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | Manduca sexta | 20-hydroxyecdysone + A + H2O | - |
? | |
ecdysone + NADPH + H+ + O2 | - |
Drosophila melanogaster | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
ecdysone + NADPH + H+ + O2 | - |
Aedes aegypti | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
ecdysone + NADPH + H+ + O2 | - |
Manduca sexta | 20-hydroxyecdysone + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
E-20-M | - |
Drosophila melanogaster |
E-20-M | - |
Aedes aegypti |
E-20-M | - |
Manduca sexta |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Drosophila melanogaster |
7.5 | - |
assay at | Aedes aegypti |
7.5 | - |
assay at | Manduca sexta |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | a cytochrome P450-dependent hydroxylase | Drosophila melanogaster | |
cytochrome P450 | a cytochrome P450-dependent hydroxylase | Aedes aegypti | |
cytochrome P450 | a cytochrome P450-dependent hydroxylase | Manduca sexta | |
NADPH | - |
Drosophila melanogaster | |
NADPH | - |
Aedes aegypti |