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Literature summary for 1.14.99.22 extracted from

  • Drummond, C.A.; Vandock, K.P.; Smith, S.L.; Fioravanti, C.F.
    Cyclic 3',5' guanosine monophosphate and larval midgut ecdysone 20-monooxygenase activity of the tobacco hornworm, Manduca sexta (2010), Comp. Biochem. Physiol. B, 157, 33-38.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dibutyryl-cGMP activates E20M activity by 50fold, diminished by injections of guanylate cyclase inhibitors alone or combined with ecdysone agonist RH-5849 Manduca sexta
additional information no activation by dibutyryl cAMP, cGMP, or cAMP Manduca sexta

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadizolo[4,3-a]-quinoxalin-1-one a guanylate cyclase inhibitor, applied with ecdysone agonist RH-5849 results in 63% reduced E20M activity Manduca sexta
6-anilinoquinoline-5,6-quinone LY-38583, a guanylate cyclase inhibitor, applied with ecdysone agonist RH-5849 results in 80% reduced E20M activity, addition of guanylate cyclase activator S levels the activity to 78% of control activity Manduca sexta
methylene blue a guanylate cyclase inhibitor, applied with ecdysone agonist RH-5849 results in 86% reduced E20M activity, reversed by addition of dibutyryl-cGMP/theophylline to 87% of control activity Manduca sexta
additional information inhibitory effects of guanylate cyclase inhibitors with RH-5849 in vivo, overview Manduca sexta

Organism

Organism UniProt Comment Textmining
Manduca sexta
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-
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Source Tissue

Source Tissue Comment Organism Textmining
larva during the last larval stadium of the midgut, E20M activity increases 50fold coincident with wandering onset Manduca sexta
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midgut during the last larval stadium of the midgut, E20M activity increases 50fold coincident with wandering onset Manduca sexta
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Synonyms

Synonyms Comment Organism
E20M
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Manduca sexta

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
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assay at Manduca sexta