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Literature summary for 1.14.99.22 extracted from

  • Vandock, K.P.; Drummond, C.A.; Smith, S.L.; Fioravanti, C.F.
    Midgut and fatbody mitochondrial transhydrogenase activities during larval-pupal development of the tobacco hornworm, Manduca sexta (2010), J. Insect Physiol., 56, 774-779.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Manduca sexta 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ecdysone + NADPH + H+ + O2 Manduca sexta
-
20-hydroxyecdysone + NADP+ + H2O
-
?
additional information Manduca sexta E20-M preferentially uses NADPH in catalyzing ecdysone conversion to the physiologically active molting hormone, 20-hydroxyecdysone ?
-
?

Organism

Organism UniProt Comment Textmining
Manduca sexta
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fat body
-
Manduca sexta
-
midgut during the ten-day developmental period preceding the larval-pupal molt, fifth larval instar, onset of wandering behavior and a 50fold increase in ecdysone 20-monooxygenase activity occur Manduca sexta
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ecdysone + NADPH + H+ + O2
-
Manduca sexta 20-hydroxyecdysone + NADP+ + H2O
-
?
additional information E20-M preferentially uses NADPH in catalyzing ecdysone conversion to the physiologically active molting hormone, 20-hydroxyecdysone Manduca sexta ?
-
?

Synonyms

Synonyms Comment Organism
E20-M
-
Manduca sexta

Cofactor

Cofactor Comment Organism Structure
NADPH preferred cofactor Manduca sexta

General Information

General Information Comment Organism
additional information physiological and developmental significance of the mitochondrial, NADPH-forming energy-linked transhydrogenations, that catalyzes a reversible hydride ion transfer between NADP(H) and NAD(H), for E20-M activity. NADPH-forming activity occurs as a nonenergy- or energy-linked activity with energy for the latter derived from either electron transport-dependent NADH or succinate utilization, or ATP hydrolysis by Mg2+-dependent ATPase, overview Manduca sexta
physiological function essential need for conversion of the molting hormone, ecdysone, to its physiologically active form, 20-hydroxyecdysone by E20-M during the post-embryonic development Manduca sexta