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Literature summary for 1.14.99.24 extracted from
- Heterogeneous natures of the microbial steroid 9alpha-hydroxylase in nocardioforms (1997), Arch. Pharm. Res., 20, 519-524.
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | enzyme occurs in many bacterial genera used in industrial processes | Corynebacterium sp. |
| synthesis | enzyme occurs in many bacterial genera used in industrial processes | Mycobacterium sp. |
| synthesis | enzyme occurs in many bacterial genera used in industrial processes | Nocardia sp. |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,2'-bipyridine | - |
Corynebacterium sp. |  |
| 2,2'-bipyridine | - |
Nocardia sp. | |
| 2,2'-bipyridine | - |
Rhodococcus erythropolis | |
| 8-hydroxyquinoline | - |
Corynebacterium sp. | |
| 8-hydroxyquinoline | - |
Mycobacterium sp. | |
| 8-hydroxyquinoline | - |
Rhodococcus erythropolis | |
| 8-hydroxyquinoline | - |
Rhodococcus rhodochrous | |
| Metyrapone | - |
Mycobacterium sp. | |
| o-phenanthroline | - |
Corynebacterium sp. | |
| o-phenanthroline | - |
Mycobacterium sp. | |
| o-phenanthroline | - |
Rhodococcus erythropolis | |
| o-phenanthroline | - |
Rhodococcus rhodochrous | |
| Sodium cyanide | - |
Corynebacterium sp. | |
| Sodium cyanide | - |
Mycobacterium sp. | |
| Sodium cyanide | - |
Rhodococcus erythropolis | |
| Sodium cyanide | - |
Rhodococcus rhodochrous | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Corynebacterium sp. | 5737 | - |
| cytoplasm | - |
Nocardia sp. | 5737 | - |
| cytoplasm | - |
Rhodococcus sp. | 5737 | - |
| cytosol | - |
Mycobacterium sp. | 5829 | - |
| cytosol | - |
Nocardia sp. | 5829 | - |
| cytosol | - |
Mycolicibacterium fortuitum | 5829 | - |
| membrane | - |
Corynebacterium sp. | 16020 | - |
| membrane | - |
Nocardia sp. | 16020 | - |
| membrane | - |
Rhodococcus sp. | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Rhodococcus rhodochrous | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Corynebacterium sp. | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Mycobacterium sp. | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Nocardia sp. | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Rhodococcus sp. | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Rhodococcus erythropolis | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Mycolicibacterium fortuitum | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Nocardia sp. M117 | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Rhodococcus rhodochrous KCTC 1061 / ATCC 17895 | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Rhodococcus erythropolis KCTC 1062 | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Corynebacterium sp. | - |
synonym Nocardia restrictus, ATCC 14887 (MCI 1354) | - |
| Mycobacterium sp. | - |
- |
- |
| Mycolicibacterium fortuitum | - |
KCTC 1122, ATCC 6842 | - |
| Nocardia sp. | - |
- |
- |
| Nocardia sp. M117 | - |
- |
- |
| Rhodococcus erythropolis | - |
synonym Nocardia erythropolis | - |
| Rhodococcus erythropolis KCTC 1062 | - |
synonym Nocardia erythropolis | - |
| Rhodococcus rhodochrous | - |
synonym Nocardia erythropolis | - |
| Rhodococcus rhodochrous KCTC 1061 / ATCC 17895 | - |
synonym Nocardia erythropolis | - |
| Rhodococcus sp. | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Nocardia sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Rhodococcus rhodochrous | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Corynebacterium sp. | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Mycobacterium sp. | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Nocardia sp. | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Rhodococcus sp. | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Rhodococcus erythropolis | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Mycolicibacterium fortuitum | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Nocardia sp. M117 | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Rhodococcus rhodochrous KCTC 1061 / ATCC 17895 | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Rhodococcus erythropolis KCTC 1062 | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
| 9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2 | - |
Rhodococcus rhodochrous | 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O | - |
? | |
| 9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2 | - |
Corynebacterium sp. | 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O | - |
? | |
| 9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2 | - |
Mycobacterium sp. | 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O | - |
? | |
| 9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2 | - |
Rhodococcus sp. | 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O | - |
? | |
| 9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2 | - |
Rhodococcus erythropolis | 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O | - |
? | |
| 9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2 | - |
Rhodococcus rhodochrous KCTC 1061 / ATCC 17895 | 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O | - |
? | |
| 9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2 | - |
Rhodococcus erythropolis KCTC 1062 | 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P450 | - |
Mycobacterium sp. | |
| NADH | - |
Mycobacterium sp. | |
| NADH | - |
Nocardia sp. | |
| NADH | - |
Mycolicibacterium fortuitum | |
| NADPH | - |
Rhodococcus rhodochrous | |
| NADPH | - |
Nocardia sp. | |
| NADPH | - |
Rhodococcus sp. | |
| NADPH | - |
Rhodococcus erythropolis | |
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