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Literature summary for 1.14.99.48 extracted from

  • Loutet, S.A.; Kobylarz, M.J.; Chau, C.H.; Murphy, M.E.
    IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus (2013), J. Biol. Chem., 288, 25749-25759.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.48

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus
-
 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus
-
 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus
-
 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus
-
 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus N315
-
 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus N315
-
 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus N315
-
 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2 Staphylococcus aureus N315
-
 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus Q7A649 isoform IsdG
-
Staphylococcus aureus Q7A827 isoform IsdI
-
Staphylococcus aureus N315 Q7A649 isoform IsdG
-
Staphylococcus aureus N315 Q7A827 isoform IsdI
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus N315 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus N315 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus N315 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus N315 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus N315 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?
protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus N315 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins ?

General Information

General Information Comment Organism
physiological function oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid Staphylococcus aureus