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Literature summary for 1.15.1.1 extracted from

  • Raimondi, S.; Uccelletti, D.; Matteuzzi, D.; Pagnoni, U.M.; Rossi, M.; Palleschi, C.
    Characterization of the superoxide dismutase SOD1 gene of Kluyveromyces marxianus L3 and improved production of SOD activity (2008), Appl. Microbiol. Biotechnol., 77, 1269-1277.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene KmSod1, DNA and amino acid sequence determination and analysis, sequence comparisons, overexpression of Cu/Zn-SOD under the control of the KlADH4 promoter in strain L3 from a multicopy plasmid, subcloning in Escherichia coli strain DH5alpha Kluyveromyces marxianus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of recombinant Cu/Zn-SOD1 in strain L3 does not significantly increase the SOD specific activity, and in some cases, a net reduction of the enzymatic activity occurs, cell phenotypes, overview Kluyveromyces marxianus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ isozyme Cu/Zn-SOD, the highly conserved histidine residues H47, H49, H64, H72, H81, and H121 are involved in the interaction with the metallic cofactors, which are essential for activity and folding in all the Sod1 enzymes, D84 is also involve in Cu2+ binding Kluyveromyces marxianus
Zn2+ isozyme Cu/Zn-SOD, the highly conserved histidine residues H47, H49, H64, H72, H81, and H121 are involved in the interaction with the metallic cofactors, which are essential for activity and folding in all the Sod1 enzymes Kluyveromyces marxianus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
15882
-
x * 15882, Cu/Zn-SOD sequence calculation Kluyveromyces marxianus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Kluyveromyces marxianus SOD activity is one major defense line against oxidative stress for all of the aerobic organisms ?
-
?
additional information Kluyveromyces marxianus L3 SOD activity is one major defense line against oxidative stress for all of the aerobic organisms ?
-
?
O2.- + H+ Kluyveromyces marxianus
-
O2 + H2O2
-
?
O2.- + H+ Kluyveromyces marxianus L3
-
O2 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Kluyveromyces marxianus B0B552 SOD1; gene KmSod1
-
Kluyveromyces marxianus L3 B0B552 SOD1; gene KmSod1
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
Cu/Zn-SOD activity in overexpressing cells from different culture conditions, overview Kluyveromyces marxianus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SOD activity is one major defense line against oxidative stress for all of the aerobic organisms Kluyveromyces marxianus ?
-
?
additional information SOD activity is one major defense line against oxidative stress for all of the aerobic organisms Kluyveromyces marxianus L3 ?
-
?
O2.- + H+
-
Kluyveromyces marxianus O2 + H2O2
-
?
O2.- + H+
-
Kluyveromyces marxianus L3 O2 + H2O2
-
?

Subunits

Subunits Comment Organism
? x * 15882, Cu/Zn-SOD sequence calculation Kluyveromyces marxianus

Synonyms

Synonyms Comment Organism
Cu/Zn superoxide dismutase
-
Kluyveromyces marxianus
Cu/Zn-SOD
-
Kluyveromyces marxianus
KmSod1p
-
Kluyveromyces marxianus
SOD
-
Kluyveromyces marxianus
SOD1
-
Kluyveromyces marxianus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Kluyveromyces marxianus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Kluyveromyces marxianus

pI Value

Organism Comment pI Value Maximum pI Value
Kluyveromyces marxianus Cu/Zn-SOD sequence calculation
-
6.39