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Literature summary for 1.15.1.1 extracted from

  • Abreu, I.A.; Hearn, A.; An, H.; Nick, H.S.; Silverman, D.N.; Cabelli, D.E.
    The kinetic mechanism of manganese-containing superoxide dismutase from Deinococcus radiodurans: a specialized enzyme for the elimination of high superoxide concentrations (2008), Biochemistry, 47, 2350-2356.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
from genomic DNA, expression in Escherichia coli strain QC774 Deinococcus radiodurans

Protein Variants

Protein Variants Comment Organism
Y34F the mutant shows metalcofactor kinetics similar to the human not the Deinococcus radiodurans Mn-SOD, formation of human-like Mn3+SOD and human-like Mn3+SOD-O2 - adduct, overview Deinococcus radiodurans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information rate constants and kinetic mechanism Deinococcus radiodurans

Metals/Ions

Metals/Ions Comment Organism Structure
Manganese when the Deinococcus radiodurans Mn2+SOD reacts with a substoichiometric amount of superoxide, Deinococcus radiodurans Mn3+SOD is produced Deinococcus radiodurans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22000
-
x * 22000, recombinant Mn-SOD, SDS-PAGE Deinococcus radiodurans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O2.- + H+ Deinococcus radiodurans Deinococcus radiodurans Mn-SOD is most effective at high superoxide fluxes found under conditions of high radioactivity compared to te enzyme of Escherichia coli and Homo sapiens O2 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Deinococcus radiodurans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Mn-SOD from Escherichia coli strain QC774 by anion exchange chromatography Deinococcus radiodurans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O2.- + H+
-
Deinococcus radiodurans O2 + H2O2
-
?
O2.- + H+ Deinococcus radiodurans Mn-SOD is most effective at high superoxide fluxes found under conditions of high radioactivity compared to te enzyme of Escherichia coli and Homo sapiens Deinococcus radiodurans O2 + H2O2
-
?

Subunits

Subunits Comment Organism
? x * 22000, recombinant Mn-SOD, SDS-PAGE Deinococcus radiodurans

Synonyms

Synonyms Comment Organism
manganese-containing superoxide dismutase
-
Deinococcus radiodurans
MnSOD
-
Deinococcus radiodurans

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Deinococcus radiodurans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Deinococcus radiodurans