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Literature summary for 1.17.1.8 extracted from
- A new flavin enzyme catalyzing the reduction of dihydrodipicolinate in sporulating Bacillus subtilis I. Purification and properties (1975), J. Biochem., 77, 405-413.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Bacillus subtilis |  |
| Cd2+ | - |
Bacillus subtilis | |
| Cu2+ | - |
Bacillus subtilis | |
| dipicolinate | - |
Bacillus subtilis | |
| Fe3+ | - |
Bacillus subtilis | |
| additional information | no inhibition by lysine and diaminopimelate | Bacillus subtilis |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18500 | - |
4 * 18500, SDS-PAGE | Bacillus subtilis |
| 74000 | - |
gel filtration | Bacillus subtilis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-dihydrodipicolinate + NAD(P)H | Bacillus subtilis | - |
2,3,4,5-tetrahydrodipicolinate + NAD(P)+ | - |
? | |
| 2,3-dihydrodipicolinate + NAD(P)H | Bacillus subtilis PCI 219 | - |
2,3,4,5-tetrahydrodipicolinate + NAD(P)+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
PCI 219 | - |
| Bacillus subtilis PCI 219 | - |
PCI 219 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bacillus subtilis |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 56.4 | - |
purified enzyme | Bacillus subtilis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-dihydrodipicolinate + NAD(P)H | - |
Bacillus subtilis | 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ | - |
? | |
| 2,3-dihydrodipicolinate + NAD(P)H | - |
Bacillus subtilis PCI 219 | 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 18500, SDS-PAGE | Bacillus subtilis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.1 | - |
- |
Bacillus subtilis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.2 | 7.5 | - |
Bacillus subtilis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | 2 mol per mol of enzyme | Bacillus subtilis | |
| NADH | slight activity | Bacillus subtilis | |
| NADPH | 3-4 times more effective than NADH | Bacillus subtilis | |
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