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Literature summary for 1.17.3.2 extracted from

  • Gongora, L.; Manez, S.; Giner, R.M.; Recio, M.d.C.; Schinella, G.; Rios, J.L.
    Inhibition of xanthine oxidase by phenolic conjugates of methylated quinic acid (2003), Planta Med., 69, 396-401.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-O-(4''-O-caffeoyl)-beta-glucopyranosyl-1,4-dihydroxy-2-(3',3'-dimethylallyl)benzene
-
Bos taurus
3,4-di-O-caffeoylquinic acid methyl ester reversible inhibition, IC50: 0.0036 mM Bos taurus
3,5-di-O-caffeoylquinic acid
-
Bos taurus
4,5-di-O-caffeoylquinic acid
-
Bos taurus
4,5-di-O-caffeoylquinic acid methyl ester reversible inhibition Bos taurus
allopurinol IC50: 0.0026 mM Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + H2O + O2
-
Bos taurus urate + H2O2
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00024
-
4,5-di-O-caffeoylquinic acid methyl ester 25°C Bos taurus
0.0031
-
3,4-di-O-caffeoylquinic acid methyl ester 25°C Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0026
-
IC50: 0.0026 mM Bos taurus allopurinol
0.0036
-
reversible inhibition, IC50: 0.0036 mM Bos taurus 3,4-di-O-caffeoylquinic acid methyl ester