Literature summary for 1.17.3.2 extracted from

Inkster, M.E.; Cotter, M.A.; Cameron, N.E.
Treatment with the xanthine oxidase inhibitor, allopurinol, improves nerve and vascular function in diabetic rats (2007), Eur. J. Pharmacol., 561, 63-71.

Search for more literature for 1.17.3.2

Application

Application	Comment	Organism
pharmacology	inhibition of xanthine oxidase is a potential therapeutic approach to diabetic neuropathy and vasculopathy	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
allopurinol	treatment with the inhibitor improves nerve and vascular function in diabetic rats, sciatic nerve and superior cervical ganglion blood flow is halved by diabetes and allopurinol corrects this by approximately 63%, Ngamma-nitro-L-arginine acts as an antagonist, effects on diabetic and non-diabetic rats, overview	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
xanthine + H2O + O2	Rattus norvegicus	xanthine oxidase is an important source of reactive oxygen species that contributes to neurovascular dysfunction in experimental diabetes, overview	urate + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male sprague-dawley rats	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
xanthine + H2O + O2	production of superoxide radicals	Rattus norvegicus	urate + H2O2	-	?
xanthine + H2O + O2	xanthine oxidase is an important source of reactive oxygen species that contributes to neurovascular dysfunction in experimental diabetes, overview	Rattus norvegicus	urate + H2O2	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)