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Literature summary for 1.17.3.2 extracted from

  • Wang, G.F.; Shang, Y.J.; Jiao, B.H.; Huang, C.G.
    Renierol from marine sponge Haliclona sp.: a natural inhibitor of xanthine oxidase with hypouricemic effects (2008), J. Enzyme Inhib. Med. Chem., 23, 406-410.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
renierol a natural enzyme inhibitor from the marine sponge Haliclona sp. Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxanthine + 2 H2O + 2 O2 Mus musculus production of superoxide radicals urate + 2 H2O2
-
?
xanthine + H2O + O2 Mus musculus production of superoxide radicals urate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
male ICR mice
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine + 2 H2O + 2 O2 production of superoxide radicals Mus musculus urate + 2 H2O2
-
?
xanthine + H2O + O2 production of superoxide radicals Mus musculus urate + H2O2
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.36 1.85 pH 7.5, inhibition of superoxide and urate production, respectively Mus musculus renierol