Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apoptotic lymphocyte microparticles | microparticles are membrane vesicles released during cell activation and apoptosis, they activate reactive oxygen species production by xanthine oxidase in endothelial cells and aorta, inhibition of phosphoinositol 3-kinase enhances the activating effect, xanthine oxidase inhibitors reduce it, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells, overview | ? | - |
? | |
xanthine + H2O + O2 | Homo sapiens | production of reactive oxygen species via superoxide radicals involved in endothelial dysfunction | urate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Homo sapiens | - |
CCRF-CEM cell | a lymphoid cell line | Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells, overview | Homo sapiens | ? | - |
? | |
xanthine + H2O + O2 | production of reactive oxygen species via superoxide radicals involved in endothelial dysfunction | Homo sapiens | urate + H2O2 | - |
? | |
xanthine + H2O + O2 | production of superoxide radicals | Homo sapiens | urate + H2O2 | - |
? |