Activating Compound | Comment | Organism | Structure |
---|---|---|---|
potassium oxonate | slight activation in vivo | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
allopurinol | 40% inhibition at 0.0285 g per kg body weight | Rattus norvegicus | |
asperuloside | from Paederia scandens extract | Rattus norvegicus | |
additional information | alcoholic extract of air-dried aerial parts of the plant Paederia scandens has inhibitory activity on the enzyme and in vivo antihypouricemic activity in hyperuricemic rats pretreated with potassium oxonate, overview, no inhibition by benzbromarone and potassium oxonate | Rattus norvegicus | |
paederoside | from Paederia scandens extract | Rattus norvegicus | |
scandoside | from Paederia scandens extract | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
xanthine + H2O + O2 | Rattus norvegicus | - |
urate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.003 | - |
crude, cell-free liver enzyme extract | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
xanthine + H2O + O2 | - |
Rattus norvegicus | urate + H2O2 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |