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Literature summary for 1.17.3.2 extracted from

  • Yan, H.; Ma, Y.; Liu, M.; Zhou, L.
    The dual actions of Paederia scandens extract as a hypouricemic agent: xanthine oxidase inhibitory activity and uricosuric effect (2008), Planta Med., 74, 1345-1350.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
potassium oxonate slight activation in vivo Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
allopurinol 40% inhibition at 0.0285 g per kg body weight Rattus norvegicus
asperuloside from Paederia scandens extract Rattus norvegicus
additional information alcoholic extract of air-dried aerial parts of the plant Paederia scandens has inhibitory activity on the enzyme and in vivo antihypouricemic activity in hyperuricemic rats pretreated with potassium oxonate, overview, no inhibition by benzbromarone and potassium oxonate Rattus norvegicus
paederoside from Paederia scandens extract Rattus norvegicus
scandoside from Paederia scandens extract Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + H2O + O2 Rattus norvegicus
-
urate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.003
-
crude, cell-free liver enzyme extract Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + H2O + O2
-
Rattus norvegicus urate + H2O2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Rattus norvegicus