Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3,6,7-tetrahydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(2,4-dichlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(2,6-dichlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(2-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(2-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(2-fluorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(3-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(3-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(3-fluorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(4-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(4-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
1-[(4-fluorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | - |
Bos taurus | |
2-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile | - |
Bos taurus | |
3,6,7-trihydroxy-1-[(2-methylbenzyl)oxy]-9H-xanthen-9-one | - |
Bos taurus | |
3,6,7-trihydroxy-1-[(2-nitrobenzyl)oxy]-9H-xanthen-9-one | - |
Bos taurus | |
3,6,7-trihydroxy-1-[(3-methylbenzyl)oxy]-9H-xanthen-9-one | - |
Bos taurus | |
3,6,7-trihydroxy-1-[(3-nitrobenzyl)oxy]-9H-xanthen-9-one | - |
Bos taurus | |
3,6,7-trihydroxy-1-[(4-methylbenzyl)oxy]-9H-xanthen-9-one | - |
Bos taurus | |
3,6,7-trihydroxy-1-[(4-nitrobenzyl)oxy]-9H-xanthen-9-one | - |
Bos taurus | |
3-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile | - |
Bos taurus | |
4-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile | - |
Bos taurus | |
additional information | xanthone derivatives as xanthine oxidase inhibitors, synthesis of a series of xanthone derivatives, overview. No inhibition by 8d, 8e, 8f, 8h, 8j, 8k, 8m, 8n, 8o, 8p, 8q, 8s, and 8t | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Bos taurus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
milk | - |
Bos taurus | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00467 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | 4-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile | |
0.0047 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | 1-[(4-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | |
0.00573 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | 3,6,7-trihydroxy-1-[(4-methylbenzyl)oxy]-9H-xanthen-9-one | |
0.00641 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | 1-[(2-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | |
0.00708 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | 3,6,7-trihydroxy-1-[(2-methylbenzyl)oxy]-9H-xanthen-9-one | |
0.01356 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | 3,6,7-trihydroxy-1-[(3-methylbenzyl)oxy]-9H-xanthen-9-one | |
0.02006 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | 1-[(4-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one | |
0.02173 | - |
pH not specified in the publication, temperature not specified in the publication | Bos taurus | 1,3,6,7-tetrahydroxy-9H-xanthen-9-one |
General Information | Comment | Organism |
---|---|---|
metabolism | xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid | Bos taurus |