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Literature summary for 1.17.3.2 extracted from

  • Hu, L.; Hu, H.; Wu, W.; Chai, X.; Luo, J.; Wu, Q.
    Discovery of novel xanthone derivatives as xanthine oxidase inhibitors (2011), Bioorg. Med. Chem. Lett., 21, 4013-4015.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3,6,7-tetrahydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(2,4-dichlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(2,6-dichlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(2-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(2-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(2-fluorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(3-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(3-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(3-fluorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(4-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(4-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
1-[(4-fluorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
Bos taurus
2-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile
-
Bos taurus
3,6,7-trihydroxy-1-[(2-methylbenzyl)oxy]-9H-xanthen-9-one
-
Bos taurus
3,6,7-trihydroxy-1-[(2-nitrobenzyl)oxy]-9H-xanthen-9-one
-
Bos taurus
3,6,7-trihydroxy-1-[(3-methylbenzyl)oxy]-9H-xanthen-9-one
-
Bos taurus
3,6,7-trihydroxy-1-[(3-nitrobenzyl)oxy]-9H-xanthen-9-one
-
Bos taurus
3,6,7-trihydroxy-1-[(4-methylbenzyl)oxy]-9H-xanthen-9-one
-
Bos taurus
3,6,7-trihydroxy-1-[(4-nitrobenzyl)oxy]-9H-xanthen-9-one
-
Bos taurus
3-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile
-
Bos taurus
4-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile
-
Bos taurus
additional information xanthone derivatives as xanthine oxidase inhibitors, synthesis of a series of xanthone derivatives, overview. No inhibition by 8d, 8e, 8f, 8h, 8j, 8k, 8m, 8n, 8o, 8p, 8q, 8s, and 8t Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
Bos taurus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00467
-
pH not specified in the publication, temperature not specified in the publication Bos taurus 4-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile
0.0047
-
pH not specified in the publication, temperature not specified in the publication Bos taurus 1-[(4-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
0.00573
-
pH not specified in the publication, temperature not specified in the publication Bos taurus 3,6,7-trihydroxy-1-[(4-methylbenzyl)oxy]-9H-xanthen-9-one
0.00641
-
pH not specified in the publication, temperature not specified in the publication Bos taurus 1-[(2-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
0.00708
-
pH not specified in the publication, temperature not specified in the publication Bos taurus 3,6,7-trihydroxy-1-[(2-methylbenzyl)oxy]-9H-xanthen-9-one
0.01356
-
pH not specified in the publication, temperature not specified in the publication Bos taurus 3,6,7-trihydroxy-1-[(3-methylbenzyl)oxy]-9H-xanthen-9-one
0.02006
-
pH not specified in the publication, temperature not specified in the publication Bos taurus 1-[(4-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
0.02173
-
pH not specified in the publication, temperature not specified in the publication Bos taurus 1,3,6,7-tetrahydroxy-9H-xanthen-9-one

General Information

General Information Comment Organism
metabolism xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid Bos taurus