Literature summary for 1.17.4.1 extracted from

Yu, Y.; Suryo Rahmanto, Y.; Hawkins, C.L.; Richardson, D.R.
The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity (2011), Mol. Pharmacol., 79, 921-931.

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Application

Application	Comment	Organism
medicine	thiosemicarbazone chelators 2-[di(pyridin-2-yl)methylidene]-N,N-dimethylhydrazinecarbothioamide and 2-(diphenylmethylidene)-N,N-dimethylhydrazinecarbothioamide possess potent and selective antitumor activity and may have an additional mechanism of ribonucleotide reductase inhibition via their effects on major thiol-containing systems	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(diphenylmethylidene)-N,N-dimethylhydrazinecarbothioamide	metal chelator, significantly decreases ribonucleotide reductase activity, whereas the NADPH/NADP+ total ratio is not reduced	Homo sapiens
2-[di(pyridin-2-yl)methylidene]-N,N-dimethylhydrazinecarbothioamide	metal chelator, significantly decreases ribonucleotide reductase activity, whereas the NADPH/NADP+ total ratio is not reduced	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
DMS-53 cell	small cell lung carcinoma	Homo sapiens	-
SK-N-MC cell	neuroepithelioma cell	Homo sapiens	-

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Release 2023.1 (January 2023)