Literature summary for 1.17.4.2 extracted from

Ylikallio, E.; Page, J.L.; Xu, X.; Lampinen, M.; Bepler, G.; Ide, T.; Tyynismaa, H.; Weiss, R.S.; Suomalainen, A.
Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice (2010), Nucleic Acids Res., 38, 8208-8218.

Search for more literature for 1.17.4.2

Cloned(Commentary)

Cloned (Comment)	Organism
high-level overexpression of RNR subunits, Rrm1, Rrm2 and p53R2, separately or in different combinations, in mice, simultaneous expression of two RNR subunits	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of RNR transgenic mice expressing one or more subunits of RNR, phenotypes, overview	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
ribonucleotide reductase	-	Mus musculus
RNR	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	endogenous RNR transcripts are downregulated in response to large increases of mtDNA in mice, which is indicative of nuclear-mitochondrial crosstalk with regard to mtDNA copy number	down

General Information

General Information	Comment	Organism
metabolism	RNR is the rate-limiting enzyme in deoxyribonucleoside triphosphate, dNTP, biosynthesis	Mus musculus
additional information	high-level overexpression of RNR subunits, Rrm1, Rrm2 and p53R2, separately or in different combinations, in mice does not result in mtDNA copy number elevation. Instead, simultaneous expression of two RNR subunits leads to imbalanced dNTP pools and progressive mtDNA depletion in the skeletal muscle, without mtDNA mutagenesis, overview	Mus musculus
physiological function	RNR is the rate-limiting enzyme in deoxyribonucleoside triphosphate, dNTP, biosynthesis, with important roles in nuclear genome maintenance. RNR is also essential for maintenance of mitochondrial DNA in mammals	Mus musculus

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Release 2023.1 (January 2023)