Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Bos taurus | |
Protein disulfide isomerase | activation, together with thioredoxin/thioredoxin reductase and reduced ribonuclease | Bos taurus | |
Reduced ribonuclease | activation, together with thio-redoxin/thioredoxin reductase, EC 1.6.4.5 plus protein-disulfide isomerase more potent than DTT | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Bos taurus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Bos taurus | - |
2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000009 | - |
thioredoxin of bovine thymus | Bos taurus |
0.0000097 | - |
thioredoxin from bovine thymus as cofactor, enzyme activity in salt washed detergent-solubilized microsomes | Bos taurus |
0.0000136 | - |
thioredoxin from Escherichia coli as cofactor, enzyme activity in salt washed detergent-solubilized microsomes | Bos taurus |
0.0000256 | - |
cofactor DTT, enzyme activity in salt washed detergent-solubilized microsomes | Bos taurus |
0.0000498 | - |
thioredoxin and protein disulfide-isomerase from bovine thymus as cofactors, enzyme activity in salt washed detergent-solubilized microsomes | Bos taurus |
0.000057 | - |
thioredoxin and protein disulfide-isomerase from Escherichia coli as cofactors, enzyme activity in salt washed detergent-solubilized microsomes | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
Bos taurus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | - |
Bos taurus | vitamin K + oxidized dithiothreitol | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
reduced thioredoxin | together with thioredoxin reductase plus protein-disulfide isomerase still more effective than DTT | Bos taurus | |
thioredoxin | - |
Bos taurus |