Literature summary for 1.17.4.4 extracted from

Jin, D.Y.; Tie, J.K.; Stafford, D.W.
The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines (2007), Biochemistry, 46, 7279-7283.

Search for more literature for 1.17.4.4

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Sf9 cell	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C132A	no catalytic activity, part of CXXC motif	Homo sapiens
C135A	no catalytic activity, part of CXXC motif	Homo sapiens
C16A	40% of wild-type activity	Homo sapiens
C43A	35% of wild-type activity. C43 can form a disulfide bond with C51	Homo sapiens
C43A/C51A	112% of wild-type activity	Homo sapiens
C51A	95% of wild-type activity. C43 can form a disulfide bond with C51	Homo sapiens
C85A	100% of wild-type activity	Homo sapiens
C96A	45% of wild-type activity	Homo sapiens
DELTAC43-C51	85% of wild-type activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
warfarin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.004	-	warfarin	wild-type, pH 8.6, 30°C	Homo sapiens
0.012	-	warfarin	mutant C43A, pH 8.6, 30°C	Homo sapiens

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Release 2023.1 (January 2023)