Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Molybdenum | molybdopterin enzyme | Aromatoleum aromaticum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ethylbenzene + H2O + acceptor | Aromatoleum aromaticum | - |
(S)-1-phenylethanol + reduced acceptor | - |
? | |
additional information | Aromatoleum aromaticum | EBDH is a bacterial molybdopterin enzyme capable of stereospecific anaerobic hydroxylation of alkylaromatic compounds to secondary alcohols | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aromatoleum aromaticum | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor | ethylbenzene oxidation mechanism involving active site residue His192, and two one-electron transfers and a radical-type intermediate have lower energy barriers than the corresponding two-electron transfer mechanisms, modeling, overview | Aromatoleum aromaticum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ethylbenzene + H2O + acceptor | - |
Aromatoleum aromaticum | (S)-1-phenylethanol + reduced acceptor | - |
? | |
additional information | EBDH is a bacterial molybdopterin enzyme capable of stereospecific anaerobic hydroxylation of alkylaromatic compounds to secondary alcohols | Aromatoleum aromaticum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EBDH | - |
Aromatoleum aromaticum |
ethylbenzene dehydrogenase | - |
Aromatoleum aromaticum |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 9 | - |
Aromatoleum aromaticum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
molybdenum cofactor | - |
Aromatoleum aromaticum |
General Information | Comment | Organism |
---|---|---|
physiological function | EBDH is a bacterial molybdopterin enzyme capable of stereospecific anaerobic hydroxylation of alkylaromatic compounds to secondary alcohols. It is a key biocatalyst in the metabolism of ethylbenzene-degrading bacteria such as Aromatoleum aromaticum, which converts ethylbenzene to (S)-1-phenylethanol | Aromatoleum aromaticum |