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Literature summary for 1.2.1.11 extracted from

  • Black, S.; Wright, N.G.
    Aspartic beta-semialdehyde dehydrogenase and aspartic beta-semialdehyde (1955), J. Biol. Chem., 213, 39-50.
    View publication on PubMed
Search for more literature for 1.2.1.11

Inhibitors

Inhibitors Comment Organism Structure
iodoacetate inhibition of arsenolysis, inhibition of the reduction of beta-aspartyl phosphate Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.036
-
 NADP+
-
 Saccharomyces cerevisiae
0.083
-
 NADPH
-
 Saccharomyces cerevisiae
0.16
-
 L-4-aspartyl phosphate
-
 Saccharomyces cerevisiae
2.6
-
 L-aspartate 4-semialdehyde
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-4-aspartyl phosphate + NADPH Saccharomyces cerevisiae
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using heat treatment, acid precipitation, protamine sulfate treatment and ammonium sulfate precipitation Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-4-aspartyl phosphate + NADPH
-
 Saccharomyces cerevisiae L-aspartate 4-semialdehyde + phosphate + NADP+
-
 ?
L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Saccharomyces cerevisiae L-4-aspartyl phosphate + NADPH
-
 r
additional information when arsenate is substituted for phosphate the rates are about one-half those with corresponding phosphate concentrations Saccharomyces cerevisiae ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 L-aspartyl phosphate + NADPH Saccharomyces cerevisiae
8 9 L-aspartate 4-semialdehyde + arsenate Saccharomyces cerevisiae
9
-
 L-aspartate 4-semialdehyde + PO43- Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
8.4 9.5 at pH 8.4 and pH 9.5: 50% of maximal activity, L-aspartate 4-semialdehyde + phosphate Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Saccharomyces cerevisiae