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Literature summary for 1.2.1.11 extracted from

  • Luniwal, A.; Wang, L.; Pavlovsky, A.; Erhardt, P.W.; Viola, R.E.
    Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase (2012), Bioorg. Med. Chem., 20, 2950-2956.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.11

Cloned(Commentary)

Cloned (Comment) Organism
-
 Streptococcus pneumoniae
-
 Vibrio cholerae

Inhibitors

Inhibitors Comment Organism Structure
(1R)-5-[(2-carboxyphenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Streptococcus pneumoniae
(1R)-5-[(2-carboxyphenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Vibrio cholerae
(1R)-5-[(3-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Streptococcus pneumoniae
(1R)-5-[(3-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Vibrio cholerae
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Streptococcus pneumoniae
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Vibrio cholerae
(2R,3aR)-5-[(methylsulfonyl)methyl]-2,3,3a,4-tetrahydro-1H-indole-2-carboxylate
-
 Streptococcus pneumoniae
(2R,3aR)-5-[(methylsulfonyl)methyl]-2,3,3a,4-tetrahydro-1H-indole-2-carboxylate
-
 Vibrio cholerae
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate
-
 Streptococcus pneumoniae
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate
-
 Vibrio cholerae
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate
-
 Streptococcus pneumoniae
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate
-
 Vibrio cholerae
(2R,7aR)-2,3,7,7a-tetrahydro-1H-indole-2,6-dicarboxylate
-
 Streptococcus pneumoniae
(2R,7aR)-2,3,7,7a-tetrahydro-1H-indole-2,6-dicarboxylate
-
 Vibrio cholerae
(2R,7aR)-6-hydroxy-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
-
 Streptococcus pneumoniae
(2R,7aR)-6-hydroxy-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
-
 Vibrio cholerae
(2R,7aR)-6-nitro-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
-
 Streptococcus pneumoniae
(2R,7aR)-6-nitro-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
-
 Vibrio cholerae
(2R,8aR)-2,7-dinitro-1,2,8,8a-tetrahydronaphthalene
-
 Streptococcus pneumoniae
(2R,8aR)-2,7-dinitro-1,2,8,8a-tetrahydronaphthalene
-
 Vibrio cholerae
(3aR)-2-oxo-2,3,3a,4-tetrahydro-1H-benzimidazole-5-carboxylic acid
-
 Streptococcus pneumoniae
(3aR)-2-oxo-2,3,3a,4-tetrahydro-1H-benzimidazole-5-carboxylic acid
-
 Vibrio cholerae
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one
-
 Streptococcus pneumoniae
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one
-
 Vibrio cholerae
(3aR)-5-nitro-3a,4-dihydro-1H-indene-1,3(2H)-dione
-
 Streptococcus pneumoniae
(3aR)-5-nitro-3a,4-dihydro-1H-indene-1,3(2H)-dione
-
 Vibrio cholerae
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
 Streptococcus pneumoniae
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
 Vibrio cholerae
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
 Streptococcus pneumoniae
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
 Vibrio cholerae
(7aR)-2-oxo-2,3,7,7a-tetrahydro-1H-indole-6-carboxylate
-
 Streptococcus pneumoniae
(7aR)-2-oxo-2,3,7,7a-tetrahydro-1H-indole-6-carboxylate
-
 Vibrio cholerae
(7aR)-3-(carboxylatomethyl)-6-nitro-7,7a-dihydro-1H-indole-2-carboxylate
-
 Streptococcus pneumoniae
(7aR)-3-(carboxylatomethyl)-6-nitro-7,7a-dihydro-1H-indole-2-carboxylate
-
 Vibrio cholerae
2-Aminoadipate
-
 Streptococcus pneumoniae
2-Aminoadipate
-
 Vibrio cholerae
4-nitro-N,N-diethylbenzimidazolinone
-
 Streptococcus pneumoniae
4-nitro-N,N-diethylbenzimidazolinone
-
 Vibrio cholerae
4-nitro-N,N-dimethylbenzimidazolinone
-
 Streptococcus pneumoniae
4-nitro-N,N-dimethylbenzimidazolinone
-
 Vibrio cholerae
4-nitro-N-ethylphthalimide
-
 Streptococcus pneumoniae
4-nitro-N-ethylphthalimide
-
 Vibrio cholerae
4-nitro-N-methylphthalimide
-
 Streptococcus pneumoniae
4-nitro-N-methylphthalimide
-
 Vibrio cholerae
5-(carboxylatocarbonyl)-1H-pyrrole-2-carboxylate
-
 Streptococcus pneumoniae
5-(carboxylatocarbonyl)-1H-pyrrole-2-carboxylate
-
 Vibrio cholerae
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate
-
 Streptococcus pneumoniae
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate
-
 Vibrio cholerae
dimethyl pyridine-2,5-dicarboxylate
-
 Streptococcus pneumoniae
dimethyl pyridine-2,5-dicarboxylate
-
 Vibrio cholerae
methyl 5-nitropyridine-2-carboxylate
-
 Streptococcus pneumoniae
methyl 5-nitropyridine-2-carboxylate
-
 Vibrio cholerae
thieno[2,3-b]thiophene-2,5-dicarboxylate
-
 Streptococcus pneumoniae
thieno[2,3-b]thiophene-2,5-dicarboxylate
-
 Vibrio cholerae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-4-aspartyl phosphate + NADPH + H+ Streptococcus pneumoniae
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
L-4-aspartyl phosphate + NADPH + H+ Vibrio cholerae
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-
Vibrio cholerae Q9KQG2
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptococcus pneumoniae
-
 Vibrio cholerae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-4-aspartyl phosphate + NADPH + H+
-
 Streptococcus pneumoniae L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
L-4-aspartyl phosphate + NADPH + H+
-
 Vibrio cholerae L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r

Synonyms

Synonyms Comment Organism
ASADH
-
 Streptococcus pneumoniae
ASADH
-
 Vibrio cholerae
aspartate semialdehyde dehydrogenase
-
 Streptococcus pneumoniae
aspartate semialdehyde dehydrogenase
-
 Vibrio cholerae

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Streptococcus pneumoniae
NADPH
-
 Vibrio cholerae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.086
-
 4-nitro-N,N-dimethylbenzimidazolinone in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
0.086
-
 4-nitro-N,N-dimethylbenzimidazolinone in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
0.11
-
 (1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
0.15
-
 (3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
0.18
-
 (3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
0.18
-
 (1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
0.4
-
 (3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
0.69
-
 (2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
0.89
-
 4-nitro-N-methylphthalimide in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.1
-
 4-nitro-N-methylphthalimide in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.1
-
 (3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2
-
 (2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2
-
 (2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
2.1
-
 (2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
2.6
-
 (3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
3.3
-
 (3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
4
-
 4-nitro-N-ethylphthalimide Ki above 4 mM in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
4
-
 4-nitro-N-ethylphthalimide Ki above 4 mM in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
4
-
 4-nitro-N,N-diethylbenzimidazolinone Ki above 4 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
4
-
 4-nitro-N,N-diethylbenzimidazolinone Ki above 4 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
20
-
 methyl 5-nitropyridine-2-carboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
20
-
 methyl 5-nitropyridine-2-carboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
20
-
 dimethyl pyridine-2,5-dicarboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
20
-
 dimethyl pyridine-2,5-dicarboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
20
-
 5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
20
-
 5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae