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Literature summary for 1.2.1.17 extracted from

  • Singh, R.; Lemire, J.; Mailloux, R.J.; Chenier, D.; Hamel, R.; Appanna, V.D.
    An ATP and oxalate generating variant tricarboxylic acid cycle counters aluminum toxicity in pseudomonas fluorescens (2009), PLoS ONE, 4, e7344.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.17

Metals/Ions

Metals/Ions Comment Organism Structure
Al3+ modulation of AGODH activity, exposure of the Al-challenged cells to a control medium results in a dramatic decrease in the activity of AGODH, in contrast, control cells incubated in an Al-enriched medium display an intense activity band, AGODH may be pivotal to the adaptation of Pseudomonas fluorescens to aluminium toxicity Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glyoxylate + CoA + NADP+ Pseudomonas fluorescens
-
 oxalyl-CoA + NADPH + H+
-
 r
additional information Pseudomonas fluorescens modified TCA cycle with diminished efficacy in NADH production and decreased CO2-evolving capacity, orchestrates the synthesis of oxalate, NADPH and ATP, ingredients pivotal to the survival in an aluminium environment ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 upregulation of acylating glyoxylate dehydrogenase leads to an enhanced synthesis of oxalate, a dicarboxylic acid involved in the immobilization of aluminum, exposure of the Al-challenged cells to a control medium results in a dramatic decrease in the activity of AGODH, in contrast, control cells incubated in an Al-enriched medium display an intense activity band Pseudomonas fluorescens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glyoxylate + CoA + NADP+
-
 Pseudomonas fluorescens oxalyl-CoA + NADPH + H+
-
 r
additional information modified TCA cycle with diminished efficacy in NADH production and decreased CO2-evolving capacity, orchestrates the synthesis of oxalate, NADPH and ATP, ingredients pivotal to the survival in an aluminium environment Pseudomonas fluorescens ?
-
 ?

Synonyms

Synonyms Comment Organism
acylating glyoxylate dehydrogenase
-
 Pseudomonas fluorescens
AGODH
-
 Pseudomonas fluorescens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Pseudomonas fluorescens