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Literature summary for 1.2.1.21 extracted from
- Further characterization of glycolaldehyde dehydrogenase isozymes from Escherichia coli B involvement in vitamin B6 biosynthesis (1978), Agric. Biol. Chem., 42, 2077-2081.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glycolaldehyde | substrate inhibition | Escherichia coli |  |
| glycolate | substrate inhibition | Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000000059 | - |
glycolate | isozyme A from vitamin B6 auxotroph mutant strain WG3 | Escherichia coli | |
| 0.000000069 | - |
glycolate | isozyme A | Escherichia coli | |
| 0.025 | - |
NADPH | isozyme C | Escherichia coli | |
| 0.027 | - |
glycolaldehyde | isozyme A | Escherichia coli | |
| 0.049 | - |
glycolate | isozyme C | Escherichia coli | |
| 0.067 | - |
NADP+ | isozyme A | Escherichia coli | |
| 0.094 | - |
NADPH | isozyme B | Escherichia coli | |
| 0.11 | - |
NADP+ | isozyme B | Escherichia coli | |
| 0.12 | - |
NADPH | isozyme A | Escherichia coli | |
| 0.13 | - |
NADP+ | isozyme C | Escherichia coli | |
| 0.15 | - |
NADPH | isozyme A from vitamin B6 auxotroph mutant strain WG3 | Escherichia coli | |
| 0.15 | - |
NADP+ | isozyme A from vitamin B6 auxotroph mutant strain WG3 | Escherichia coli | |
| 8.3 | - |
glycolaldehyde | isozyme C | Escherichia coli | |
| 11 | - |
glycolate | isozyme B | Escherichia coli | |
| 14 | - |
glycolaldehyde | isozyme A from vitamin B6 auxotroph mutant strain WG3 | Escherichia coli | |
| 27 | - |
glycolaldehyde | isozyme B | Escherichia coli | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | isozymes B and C | Escherichia coli | 5737 | - |
| periplasm | isozyme A | Escherichia coli | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Escherichia coli B WG1 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycolaldehyde + NAD+ + H2O | relative activity of isozymes A, B and C in wild-type strain in%: 75.2/19.7/5.2 | Escherichia coli | glycolate + NADH | - |
? | |
| glycolaldehyde + NAD+ + H2O | relative activity of isozymes A, B and C in wild-type strain in%: 75.2/19.7/5.2 | Escherichia coli B WG1 | glycolate + NADH | - |
? | |
| glycolaldehyde + NADP+ + H2O | - |
Escherichia coli | glycolate + NADPH + H+ | - |
? | |
| glycolaldehyde + NADP+ + H2O | - |
Escherichia coli B WG1 | glycolate + NADPH + H+ | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00085 | - |
glycolate | isozyme B | Escherichia coli | |
| 0.0021 | - |
glycolaldehyde | isozyme A | Escherichia coli | |
| 0.004 | - |
glycolaldehyde | isozyme B | Escherichia coli | |
| 0.085 | - |
glycolate | isozyme A | Escherichia coli | |
| 0.13 | - |
glycolate | isozyme C | Escherichia coli | |
| 8.3 | - |
glycolaldehyde | isozyme C | Escherichia coli | |
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