Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxybenzaldehyde | - |
Rattus norvegicus | |
ADP | - |
Rattus norvegicus | |
AMP | - |
Rattus norvegicus | |
ATP | - |
Rattus norvegicus | |
benzaldehyde | - |
Rattus norvegicus | |
Chloral hydrate | - |
Rattus norvegicus | |
iodoacetamide | - |
Rattus norvegicus | |
p-bromobenzaldehyde | 1 mM, 38% inhibition | Rattus norvegicus | |
p-chlorobenzaldehyde | 1 mM, 38% inhibition | Rattus norvegicus | |
p-ethoxybenzaldehyde | 1 mM, 19% inhibition | Rattus norvegicus | |
p-ethylbenzaldehyde | 1 mM, 51% inhibition | Rattus norvegicus | |
p-fluorobenzaldehyde | 1 mM, 19% inhibition | Rattus norvegicus | |
p-iodobenzaldehyde | 1 mM, 52% inhibition | Rattus norvegicus | |
p-isopropylbenzaldehyde | 1 mM, 19% inhibition | Rattus norvegicus | |
p-Methoxybenzaldehyde | 1 mM, 19% inhibition | Rattus norvegicus | |
p-methylbenzaldehyde | 1 mM, 64% inhibition | Rattus norvegicus | |
p-nitrobenzaldehyde | 1 mM, 20% inhibition | Rattus norvegicus | |
succinate semialdehyde | - |
Rattus norvegicus | |
Valeraldehyde | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
NAD+ | - |
Rattus norvegicus | |
0.1 | - |
succinate semialdehyde | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | - |
2 * 68000, SDS-PAGE | Rattus norvegicus |
140000 | - |
gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+ | compulsory ordered mechanism where NAD+ binds first followed by succinate semialdehyde | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
27 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate semialdehyde + NAD+ + H2O | reverse reaction proceeds at 1/1230 of the rate of the forward eaction | Rattus norvegicus | succinate + NADH | - |
ir | |
succinate semialdehyde + NADP+ + H2O | reaction with NADP+ is 13% of the activity with NAD+ | Rattus norvegicus | succinate + NADPH | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 68000, SDS-PAGE | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.6 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 10 | about 50% of maximal activity at pH 7.0 and at pH 10.0 | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus |