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Literature summary for 1.2.1.3 extracted from
- Rat liver aldehyde dehydrogenase. II. Isolation and characterization of four inducible isozymes (1984), J. Biol. Chem., 259, 11991-11996.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| diethylstilbestrol | activates | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Disulfiram | - |
Rattus norvegicus | |
| p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0023 | - |
NAD+ | enzyme from promotion phase of hepatocarcinogenesis | Rattus norvegicus | |
| 0.0077 | - |
NAD+ | phenobarbital-inducible enzyme | Rattus norvegicus | |
| 1.3 | - |
propanal | enzyme from promotion phase of hepatocarcinogenesis | Rattus norvegicus | |
| 1.3 | - |
benzaldehyde | phenobarbital-inducible enzyme | Rattus norvegicus | |
| 1.4 | - |
propanal | phenobarbital-inducible enzyme | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
enzyme from the promotion phase of hepatocarcinogenesis and phenobabital-inducible enzyme | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| enzyme from promotion phase of hepatocarcinogenesis and phenobarbital-inducible enzyme | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.07 | - |
enzyme from the promotion phase of hepatocarcinogenesis | Rattus norvegicus |
| 3.86 | - |
phenobarbital-inducible enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzaldehyde + NAD+ + H2O | promotion-associated enzyme, no activity with phenobarbital-inducible enzyme | Rattus norvegicus | benzoate + NADH + H+ | - |
? | |
| phenylacetaldehyde + NAD+ + H2O | - |
Rattus norvegicus | phenylacetate + NADH + H+ | - |
? | |
| propanal + NAD+ + H2O | - |
Rattus norvegicus | propionate + NADH | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
15 min, retains 70% of the original activity | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 10 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 9 | 10 | pH 9: about 35% of maximal activity, pH 10: optimum | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | NADP+: promotion-associated enzyme shows 1% of the activity with NAD+, phenobarbital-associated enzyme shows no activity | Rattus norvegicus | |
| NAD+ | - |
Rattus norvegicus | |
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