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Literature summary for 1.2.1.3 extracted from

  • Doorn, J.A.; Hurley, T.D.; Petersen, D.R.
    Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal (2006), Chem. Res. Toxicol., 19, 102-110.
    View publication on PubMed
Search for more literature for 1.2.1.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxynon-2-enal 10% inhibition at 0.05 mM Homo sapiens
4-oxonon-2-enal 90% inhibition at 0.05 mM Homo sapiens
4-oxonon-2-enoic acid 90% inhibition at 0.05 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.183
-
 glutathione-4-oxonon-2-enal
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
 SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
p-hydroxyacetophenone Sepharose affinity column Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxynon-2-enal + NAD+
-
 Homo sapiens 4-hydroxynon-2-enoic acid + NADH
-
 ?
4-oxonon-2-enal + NAD+ + H2O
-
 Homo sapiens 4-oxonon-2-enoic acid + NADH
-
 ?
glutathione-4-oxonon-2-enal + NAD+ + H2O
-
 Homo sapiens glutathione-4-oxonon-2-enoic acid + NADH
-
 ?

Synonyms

Synonyms Comment Organism
aldehyde dehydrogenase
-
 Homo sapiens
hALDH2
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.04
-
 glutathione-4-oxonon-2-enal 50 mM sodium phosphate buffer pH 7.4, 1 mM NAD+, 37°C Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens