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Literature summary for 1.2.1.3 extracted from

  • Yao, L.; Fan, P.; Arolfo, M.; Jiang, Z.; Olive, M.F.; Zablocki, J.; Sun, H.L.; Chu, N.; Lee, J.; Kim, H.Y.; Leung, K.; Shryock, J.; Blackburn, B.; Diamond, I.
    Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis (2010), Nat. Med., 16, 1024-1028.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
-
Rattus norvegicus 3,4-dihydroxyphenylacetate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
aldehyde dehydrogenase-2
-
Rattus norvegicus
ALDH2
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction ALDH2 inhibition suppresses cocaine self-administration and seeking behavior and prevents cocaine- or cue-induced reinstatement in a rat model of cocaine relapse-like behavior Rattus norvegicus