Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
isoform ALDH2, using 100 mM Na-ACES buffer, pH 6.4-6.6, 100 mM guanidine-HCl, 10 mM MgCl2, and 4 mM dithiothreitol and 16-17% (w/v) PEG 6000 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone | - |
Homo sapiens | |
3-(1-azepanyl)-1-phenyl-1-propanone | - |
Homo sapiens | |
3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone | - |
Homo sapiens | |
3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate precipitation, column chromatography, and gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
propionaldehyde + NAD+ + H2O | - |
Homo sapiens | propionate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALD1A1 | isoform | Homo sapiens |
ALDH2 | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0022 | - |
isoform ALDH1A1, pH and temperature not specified in the publication | Homo sapiens | 3-(1-azepanyl)-1-phenyl-1-propanone | |
0.0025 | - |
isoform ALDH1A1, pH and temperature not specified in the publication | Homo sapiens | 3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone | |
0.0054 | - |
isoform ALDH2, pH and temperature not specified in the publication | Homo sapiens | 3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone | |
0.0064 | - |
isoform ALDH2, pH and temperature not specified in the publication | Homo sapiens | 3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone | |
0.0068 | - |
isoform ALDH1A1, pH and temperature not specified in the publication | Homo sapiens | 1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone | |
0.0079 | - |
isoform ALDH1A1, pH and temperature not specified in the publication | Homo sapiens | 3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone | |
0.0083 | - |
isoform ALDH2, pH and temperature not specified in the publication | Homo sapiens | 1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone | |
0.0086 | - |
isoform ALDH2, pH and temperature not specified in the publication | Homo sapiens | 3-(1-azepanyl)-1-phenyl-1-propanone |