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Literature summary for 1.2.1.31 extracted from

  • Hijarrubia, M.J.; Aparicio, J.F.; Casqueiro, J.; Martin, J.F.
    Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional.alpha-aminoadipate activating and reducing enzyme (2001), Mol. Gen. Genet., 264, 755-762.
    View publication on PubMed
Search for more literature for 1.2.1.31

Cloned(Commentary)

Cloned (Comment) Organism
cloning of lys2, the cloned gene encodes a functional alpha-aminoadipate reductase as shown by complementation of a Penicillium chrysogenum lys2 mutant, the aminoacid sequence shows strong homology with the alpha-aminoadipate reductase encoded by lys2 genes of Candida albicans, Schizosaccharomyces pombe, Saccharomyces cerevisiae and Penicillium chrysogenum Acremonium chrysogenum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alpha-aminoadipate + NAD(P)H Acremonium chrysogenum
-
 L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
 ?
additional information Acremonium chrysogenum the enzyme catalyzes both the activation of alpha-aminoadipic acid and its reduction to semialdehyde ?
-
 ?

Organism

Organism UniProt Comment Textmining
Acremonium chrysogenum
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification the lys5 gene product is functionally active and can recognize apo-Lys2, transferring a 4'-phosphopantetheinyl moiety to the conserved serine residue in the peptidyl carrier domain of the protein Acremonium chrysogenum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Acremonium chrysogenum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-2-aminoadipate + NADPH
-
 Acremonium chrysogenum L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
 ?
L-alpha-aminoadipate + NAD(P)H
-
 Acremonium chrysogenum L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
 ?
additional information the enzyme catalyzes both the activation of alpha-aminoadipic acid and its reduction to semialdehyde Acremonium chrysogenum ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADH reaction not observed Acremonium chrysogenum
NADPH
-
 Acremonium chrysogenum