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Literature summary for 1.2.1.4 extracted from

  • Seegmiller, J.E.
    Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast (1953), J. Biol. Chem., 201, 629-637.
    View publication on PubMed
Search for more literature for 1.2.1.4

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
 NADP+
-
 Saccharomyces cerevisiae
0.035
-
 acetaldehyde
-
 Saccharomyces cerevisiae
2.2
-
 glycolaldehyde
-
 Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ activates Saccharomyces cerevisiae
Ca2+ activates Saccharomyces cerevisiae
Mg2+ activates Saccharomyces cerevisiae
Mn2+ activates Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NADP+ + H2O
-
 Saccharomyces cerevisiae acetate + NADPH + H+
-
 ?
formaldehyde + NADP+ + H2O
-
 Saccharomyces cerevisiae formate + NADPH + H+
-
 ?
glycolaldehyde + NADP+ + H2O
-
 Saccharomyces cerevisiae glycolate + NADPH + H+
-
 ?
propanal + NADP+ + H2O
-
 Saccharomyces cerevisiae propionate + NADPH + H+
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
 Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
6.8 8.7 about 50% of maximal activity at pH 6.8 and 8.0 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADP+ 0.1-0.4% of the activity with NADP+ Saccharomyces cerevisiae