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Literature summary for 1.2.1.4 extracted from

  • Estey, T.; Piatigorsky, J.; Lassen, N.; Vasiliou, V.
    ALDH3A1: a corneal crystallin with diverse functions (2007), Exp. Eye Res., 84, 3-12.
    View publication on PubMed

Application

Application Comment Organism
medicine ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress Mammalia
medicine ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress Mus musculus
medicine ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress Homo sapiens
medicine ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
additional information ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure Homo sapiens
additional information ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure Mammalia
additional information ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure Mus musculus
additional information ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
trans-2-nonenal purified ALDH3A1 Mammalia
0.012
-
trans-2-nonenal purified ALDH3A1 Mus musculus
0.012
-
trans-2-nonenal purified ALDH3A1 Homo sapiens
0.012
-
trans-2-nonenal purified ALDH3A1 Oryctolagus cuniculus
0.035
-
trans-2-octenal purified ALDH3A1 Mammalia
0.035
-
trans-2-octenal purified ALDH3A1 Mus musculus
0.035
-
trans-2-octenal purified ALDH3A1 Homo sapiens
0.035
-
trans-2-octenal purified ALDH3A1 Oryctolagus cuniculus
0.045
-
4-hydroxy-2-nonenal purified recombinant human ALDH3A1 Mammalia
0.045
-
4-hydroxy-2-nonenal purified recombinant human ALDH3A1 Mus musculus
0.045
-
4-hydroxy-2-nonenal purified recombinant human ALDH3A1 Homo sapiens
0.045
-
4-hydroxy-2-nonenal purified recombinant human ALDH3A1 Oryctolagus cuniculus
0.056
-
4-hydroxy-2-nonenal in the cytosolic extracts of the ALDH3A1-transfected HCE cells Mammalia
0.056
-
4-hydroxy-2-nonenal in the cytosolic extracts of the ALDH3A1-transfected HCE cells Mus musculus
0.056
-
4-hydroxy-2-nonenal in the cytosolic extracts of the ALDH3A1-transfected HCE cells Homo sapiens
0.056
-
4-hydroxy-2-nonenal in the cytosolic extracts of the ALDH3A1-transfected HCE cells Oryctolagus cuniculus
0.155
-
trans-2-hexenal purified ALDH3A1 Mammalia
0.155
-
trans-2-hexenal purified ALDH3A1 Mus musculus
0.155
-
trans-2-hexenal purified ALDH3A1 Homo sapiens
0.155
-
trans-2-hexenal purified ALDH3A1 Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mammalia 5829
-
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Oryctolagus cuniculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an aldehyde + NADP+ + H2O Mammalia
-
an acid + NADPH + H+
-
?
an aldehyde + NADP+ + H2O Mus musculus
-
an acid + NADPH + H+
-
?
an aldehyde + NADP+ + H2O Homo sapiens
-
an acid + NADPH + H+
-
?
an aldehyde + NADP+ + H2O Oryctolagus cuniculus
-
an acid + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mammalia
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cornea
-
Mammalia
-
HCE cell
-
Homo sapiens
-
NCTC 2544 cell skin keratinocyte Homo sapiens
-
RAW-264.7 cell murine macrophages Mus musculus
-
TRK-43 cell cultured rabbit stromal fibroblasts Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxy-2-nonenal + NADP+ + H2O
-
Mammalia (2E)-4-hydroxynon-2-enoate + NADPH + H+
-
?
4-hydroxy-2-nonenal + NADP+ + H2O
-
Mus musculus (2E)-4-hydroxynon-2-enoate + NADPH + H+
-
?
4-hydroxy-2-nonenal + NADP+ + H2O
-
Homo sapiens (2E)-4-hydroxynon-2-enoate + NADPH + H+
-
?
4-hydroxy-2-nonenal + NADP+ + H2O
-
Oryctolagus cuniculus (2E)-4-hydroxynon-2-enoate + NADPH + H+
-
?
an aldehyde + NADP+ + H2O
-
Mammalia an acid + NADPH + H+
-
?
an aldehyde + NADP+ + H2O
-
Mus musculus an acid + NADPH + H+
-
?
an aldehyde + NADP+ + H2O
-
Homo sapiens an acid + NADPH + H+
-
?
an aldehyde + NADP+ + H2O
-
Oryctolagus cuniculus an acid + NADPH + H+
-
?
trans-2-hexenal + NADP+ + H2O
-
Mammalia (2E)-hex-2-enoate + NADPH + H+
-
?
trans-2-hexenal + NADP+ + H2O
-
Mus musculus (2E)-hex-2-enoate + NADPH + H+
-
?
trans-2-hexenal + NADP+ + H2O
-
Homo sapiens (2E)-hex-2-enoate + NADPH + H+
-
?
trans-2-hexenal + NADP+ + H2O
-
Oryctolagus cuniculus (2E)-hex-2-enoate + NADPH + H+
-
?
trans-2-nonenal + NADP+ + H2O
-
Mammalia (2E)-non-2-enoate + NADPH + H+
-
?
trans-2-nonenal + NADP+ + H2O
-
Mus musculus (2E)-non-2-enoate + NADPH + H+
-
?
trans-2-nonenal + NADP+ + H2O
-
Homo sapiens (2E)-non-2-enoate + NADPH + H+
-
?
trans-2-nonenal + NADP+ + H2O
-
Oryctolagus cuniculus (2E)-non-2-enoate + NADPH + H+
-
?
trans-2-octenal + NADP+ + H2O
-
Mammalia (2E)-oct-2-enoate + NADPH + H+
-
?
trans-2-octenal + NADP+ + H2O
-
Mus musculus (2E)-oct-2-enoate + NADPH + H+
-
?
trans-2-octenal + NADP+ + H2O
-
Homo sapiens (2E)-oct-2-enoate + NADPH + H+
-
?
trans-2-octenal + NADP+ + H2O
-
Oryctolagus cuniculus (2E)-oct-2-enoate + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
aldehyde dehydrogenase (NADP+)
-
Mammalia
aldehyde dehydrogenase (NADP+)
-
Mus musculus
aldehyde dehydrogenase (NADP+)
-
Homo sapiens
aldehyde dehydrogenase (NADP+)
-
Oryctolagus cuniculus
aldehyde dehydrogenase 3A1
-
Mammalia
aldehyde dehydrogenase 3A1
-
Mus musculus
aldehyde dehydrogenase 3A1
-
Homo sapiens
aldehyde dehydrogenase 3A1
-
Oryctolagus cuniculus
ALDH3A1
-
Mammalia
ALDH3A1
-
Mus musculus
ALDH3A1
-
Homo sapiens
ALDH3A1
-
Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mammalia
NADPH
-
Mus musculus
NADPH
-
Homo sapiens
NADPH
-
Oryctolagus cuniculus