Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Disulfiram | 0.025 mM, 99% inhibition of activity with NADP+, 80% inhibition of activity with activity with NAD+ | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
NAD+ | - |
Rattus norvegicus | |
0.2 | - |
benzaldehyde | enzyme from cornea, reaction with NADP+ | Rattus norvegicus | |
0.3 | - |
benzaldehyde | enzyme from HTC hepatoma cells, reaction with NADP+ | Rattus norvegicus | |
0.42 | - |
NADP+ | - |
Rattus norvegicus | |
2.7 | - |
propanal | enzyme from HTC hepatoma cells, reaction with NAD+ | Rattus norvegicus | |
3 | - |
NAD+ | enzyme from cornea, reaction with propanal | Rattus norvegicus | |
5.7 | - |
propanal | enzyme from cornea, reaction with NAD+ | Rattus norvegicus | |
35 | - |
NAD+ | enzyme from HTC hepatoma cells, reaction with propanal | Rattus norvegicus | |
240 | - |
NADP+ | enzyme from HTC hepatoma cells, reaction with benzaldehyde | Rattus norvegicus | |
260 | - |
NADP+ | enzyme from cornea, reaction with benzaldehyde | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
51000 | - |
2 * 51000, SDS-PAGE | Rattus norvegicus |
100000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme plays a role in oxidation of a variety of aldehydes generated by lipid metabolism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cornea | - |
Rattus norvegicus | - |
HTC cell | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
110.5 | - |
liver enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,5-dihydroxybenzaldehyde + NADP+ + H2O | - |
Rattus norvegicus | 2,5-dihydroxybenzoate + NADPH + H+ | - |
? | |
2-methylbutyraldehyde + NAD+ + H2O | - |
Rattus norvegicus | 2-methylbutyrate + NADH + H+ | - |
? | |
3-hydroxybenzaldehyde + NADP+ + H2O | - |
Rattus norvegicus | 3-hydroxybenzoate + NADPH + H+ | - |
? | |
4-carboxybenzaldehyde + NADP+ + H2O | - |
Rattus norvegicus | 4-carboxybenzoate + NADPH + H+ | - |
? | |
4-chlorobenzaldehyde + NADP+ + H2O | - |
Rattus norvegicus | 4-chlorobenzoate + NADPH + H+ | - |
? | |
4-nitrobenzaldehyde + NAD+ + H2O | - |
Rattus norvegicus | 4-nitrobenzoate + NADH + H+ | - |
? | |
acetaldehyde + NADP+ + H2O | - |
Rattus norvegicus | acetate + NADPH + H+ | - |
? | |
benzaldehyde + NADP+ | - |
Rattus norvegicus | benzoate + NADPH | - |
? | |
dodecanal + NADP+ + H2O | - |
Rattus norvegicus | dodecanoate + NADPH + H+ | - |
? | |
hexanal + NAD+ + H2O | - |
Rattus norvegicus | hexanoate + NADH + H+ | - |
? | |
isobutanal + NAD+ + H2O | - |
Rattus norvegicus | isobutyrate + NADH + H+ | - |
? | |
additional information | the enzyme plays a role in oxidation of a variety of aldehydes generated by lipid metabolism | Rattus norvegicus | ? | - |
? | |
nonanal + NADP+ + H2O | - |
Rattus norvegicus | nonanoate + NADPH + H+ | - |
? | |
octanal + NAD+ + H2O | - |
Rattus norvegicus | octanoate + NADH + H+ | - |
? | |
phenylacetaldehyde + NADP+ + H2O | - |
Rattus norvegicus | phenylacetate + NADPH + H+ | - |
? | |
propanal + NAD+ + H2O | - |
Rattus norvegicus | propionate + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 51000, SDS-PAGE | Rattus norvegicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
55 | - |
4 min, 98% loss of activity | Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
activity with NADP+ | Rattus norvegicus |
10 | - |
activity with NAD+, broad plateau from pH 5 to 8 followed by a sharp increase in activity to pH 10 | Rattus norvegicus |