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Literature summary for 1.2.1.5 extracted from
- Characterization of aldehyde dehydrogenase from HTC rat hepatoma cells (1985), Biochim. Biophys. Acta, 843, 180-185.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Disulfiram | 0.025 mM or 0.05 mM, 99% inhibition of activity with NADP+, 60% inhibition of activity with NAD+ | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
NAD+ | reaction with propanal | Rattus norvegicus | |
| 0.3 | - |
benzaldehyde | - |
Rattus norvegicus | |
| 0.35 | - |
NADP+ | reaction with benzaldehyde | Rattus norvegicus | |
| 2.9 | - |
propanal | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HTC cell | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 17.91 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzaldehyde + NADP+ | - |
Rattus norvegicus | benzoate + NADPH | - |
? | |
| propanal + NAD+ + H2O | - |
Rattus norvegicus | propionate + NADH + H+ | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
less than 10% of the activity with NAD+ and NADP+ remains after 2 min | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
reaction with benzaldehyde and NADP+ | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | prefers NADP+ over NAD+ | Rattus norvegicus | |
| NADP+ | prefers NADP+ over NAD+ | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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