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Literature summary for 1.2.1.5 extracted from
- Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation (2007), J. Mol. Cell. Cardiol., 42, 1111-1118.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | ALDH2 may have antioxidant properties. Yeast ALDH significantly and dose-dependently attenuates HX/XO-generated O2S- signal | Saccharomyces cerevisiae |
| additional information | reduced ALDH-2 activity and expression leads to decreased nitroglycerin bioconversion. ALDH is an important physiological inhibitory factor of superoxide production | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benomyl | potent irreversible inhibitor of ALDH. Benomyl increases superoxide production as much as nitroglycerin | Rattus norvegicus |  |
| nitroglycerin | induces nitrate tolerance. Expression and activity of ALDH-2 is decreased in nitrate-tolerant rats | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P11884 | male Wistar rats | - |
| Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta | - |
Rattus norvegicus | - |
| additional information | addition of ALDH to RASM cell homogenates significantly decreases NO consumption | Rattus norvegicus | - |
| smooth muscle | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzaldehyde + NADP+ + H2O | - |
Saccharomyces cerevisiae | benzoate + NADPH + H+ | - |
? | |
| benzaldehyde + NADP+ + H2O | - |
Rattus norvegicus | benzoate + NADPH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aldehyde dehydrogenase 2 | - |
Saccharomyces cerevisiae |
| aldehyde dehydrogenase 2 | - |
Rattus norvegicus |
| ALDH2 | - |
Saccharomyces cerevisiae |
| ALDH2 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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