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Literature summary for 1.2.1.5 extracted from

  • Marchitti, S.A.; Brocker, C.; Stagos, D.; Vasiliou, V.
    Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily (2008), Expert. Opin. Drug Metab. Toxicol., 4, 697-720.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine 19 ALDH genes are identified in the human genome and mutations in these genes and subsequent inborn errors in aldehyde metabolism are the molecular basis of several diseases, including Sjögren-Larsson syndrome, type II hyperprolinemia, gamma-hydroxybutyric aciduria and pyridoxine-dependent seizures. ALDH enzymes also play important roles in embryogenesis and development, neurotransmission, oxidative stress and cancer. ALDH enzymes display multiple catalytic and non-catalytic functions including ester hydrolysis, antioxidant properties, xenobiotic bioactivation and UV light absorption Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O
-
Homo sapiens acetate + NADH + H+
-
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Synonyms

Synonyms Comment Organism
aldehyde dehydrogenase
-
Homo sapiens
ALDH
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens