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Literature summary for 1.2.1.50 extracted from

  • Teerawanichpan, P.; Robertson, A.J.; Qiu, X.
    A fatty acyl-CoA reductase highly expressed in the head of honey bee (Apis mellifera) involves biosynthesis of a wide range of aliphatic fatty alcohols (2010), Insect Biochem. Mol. Biol., 40, 641-649.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
heterologous expression of pYES2.1 plasmid harbouring AmFAR1 in Saccharomyces cerevisiae strain INVSc1 Apis mellifera

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59200
-
calculated from sequence Apis mellifera

Organism

Organism UniProt Comment Textmining
Apis mellifera D9MWM7 honey bee
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Source Tissue

Source Tissue Comment Organism Textmining
head predominance, expression level of AmFAR1 in head approximately three times higher than in thorax and abdomen Apis mellifera
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additional information AmFAR1 ubiquitously expressed in all body segments Apis mellifera
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a long-chain fatty acyl-CoA + NADPH + H+ AmFAR1 converts saturated fatty acids ranging from 16 to 22 carbon chains to their corresponding alcohols with the highest conversion efficiency shown on 18:0, AmFAR1 also shows some activities on ricinoleic acid, 16:1n-7 and 18:1n-9 Apis mellifera a long-chain aldehyde + CoA + NADP+ aldehyde intermediate is immediately reduced to the corresponding alcohol ?
additional information no activity observed on 18:2n-6 and 18:3n-3 Apis mellifera ?
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?

Synonyms

Synonyms Comment Organism
AmFAR1
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Apis mellifera
fatty acyl-CoA reductase
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Apis mellifera

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
-
Apis mellifera

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
15 40
-
Apis mellifera

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.5
-
Apis mellifera

Cofactor

Cofactor Comment Organism Structure
NADPH no activity with NADH Apis mellifera

General Information

General Information Comment Organism
metabolism enzyme is involved in the conversion of a wide range of fatty acids to their corresponding alcohols, which are the essential components of pheromones, wax esters or ether lipids Apis mellifera