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Literature summary for 1.2.1.79 extracted from

  • Sanchez, M.; Fernandez, J.; Martin, M.; Gibello, A.; Garrido-Pertierra, A.
    Purification and properties of two succinic semialdehyde dehydrogenases from Klebsiella pneumoniae (1989), Biochim. Biophys. Acta, 990, 225-231.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory: succinate, pyruvate Klebsiella pneumoniae
NADPH
-
 Klebsiella pneumoniae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 succinate semialdehyde pH 7.8, 30°C Klebsiella pneumoniae
0.25
-
 NADP+ pH 7.8, 30°C Klebsiella pneumoniae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
300000
-
 gel filtration Klebsiella pneumoniae

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1
-
 pH 7.8, 30°C Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate semialdehyde + NADP+ + H2O
-
 Klebsiella pneumoniae succinate + NADPH + 2 H+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Klebsiella pneumoniae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 7.8
-
 Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
NADP+ specific for NADP+ Klebsiella pneumoniae