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Literature summary for 1.2.1.95 extracted from

  • Affenzeller, K.; Jaklitsch, W.; Hönlinger, C.; Kubicek, C.
    Lysine biosynthesis in Penicillium chrysogenum is regulated by feedback inhibition of alpha-aminoadipate reductase (1989), FEMS Microbiol. Lett., 58, 293-297.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
L-lysine competitive with respect to alpha-aminoadipate. Presence of Lysine inhibits incorporation of alpha-aminoadipate into protein-bound lysine Penicillium chrysogenum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
NADPH pH not specified in the publication, temperature not specified in the publication Penicillium chrysogenum
0.3
-
L-2-aminoadipate pH not specified in the publication, temperature not specified in the publication Penicillium chrysogenum
0.65
-
ATP pH not specified in the publication, temperature not specified in the publication Penicillium chrysogenum

Organism

Organism UniProt Comment Textmining
Penicillium chrysogenum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-2-aminoadipate + NADPH + H+ + ATP
-
Penicillium chrysogenum (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.26
-
L-lysine pH not specified in the publication, temperature not specified in the publication Penicillium chrysogenum