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Literature summary for 1.2.3.1 extracted from

  • Barr, J.T.; Jones, J.P.
    Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase (2013), Drug Metab. Dispos., 41, 24-29.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.3.1

Inhibitors

Inhibitors Comment Organism Structure
beta-estradiol
-
 Homo sapiens
chlorpromazine
-
 Homo sapiens
clozapine
-
 Homo sapiens
domperidone
-
 Homo sapiens
ethinyl estradiol
-
 Homo sapiens
hydralazine 100 microM reduces enzyme activity by as much as 96% Homo sapiens
menadione
-
 Homo sapiens
additional information addition of 100 microM allopurinol has no significant effect on enzyme activity Homo sapiens
raloxifene
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0063
-
 N-[(2-dimethylamino)ethyl]acridine-4-carboxamide pH 7.4 and 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2 N-[(2-dimethylamino)ethyl]acridine-4-carboxamide i.e. DACA, an experimental antitumor agent Homo sapiens DACA-9(10H)-acridone + H2O2
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000023
-
 raloxifene Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C Homo sapiens
0.00043
-
 ethinyl estradiol Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C Homo sapiens
0.00047
-
 menadione Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C Homo sapiens
0.00062
-
 chlorpromazine Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C Homo sapiens
0.00087
-
 beta-estradiol Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C Homo sapiens
0.0012
-
 domperidone Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C Homo sapiens
0.0015
-
 menadione Ki-value for enzyme-substrate complex with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C Homo sapiens
0.0036
-
 ethinyl estradiol Ki-value for enzyme-substrate complex with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C Homo sapiens
0.0044
-
 beta-estradiol Ki-value for enzyme-substrate complex with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C Homo sapiens
0.0051
-
 clozapine Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C Homo sapiens