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Literature summary for 1.2.4.1 extracted from

  • Lowe, P.N.; Leeper, F.J.; Perham, R.N.
    Stereoisomers of tetrahydrothiamin pyrophosphate, potent inhibitors of the pyruvate dehydrogenase multienzyme complex from Escherichia coli (1983), Biochemistry, 22, 150-157.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NaBH4 rapid inactivation in the presence of thiamine diphosphate, may reduce thiamine diphosphate to produce a reversible inhibitor Escherichia coli
Tetrahydrothiamine diphosphate cis-isomer, 0.0013 mM, 50% inhibition Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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