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Literature summary for 1.2.4.1 extracted from

  • Li, J.; Kato, M.; Chuang, D.T.
    Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate (2009), J. Biol. Chem., 284, 34458-34467.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
pyruvate dehydrogenase kinase dephosphorylation by pyruvatedehydrogenase phosphatase isoforms restores pyruvate dehydrogenase complex activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pyruvate dehydrogenase kinase phosphorylation of E1p by pyruvate dehydrogenase kinase isoforms inactivates the pyruvate dehydrogenase complex Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + CoA + NAD+ Homo sapiens
-
acetyl-CoA + CO2 + NADH
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA + NAD+
-
Homo sapiens acetyl-CoA + CO2 + NADH
-
?

Synonyms

Synonyms Comment Organism
E1p
-
Homo sapiens
PDC
-
Homo sapiens
pyruvate dehydrogenase complex contains of the three catalytic components pyruvate dehydrogenase (E1p), dihydrolipoyl transacetylase (E2p), and dihydrolipoamide dehydrogenase (E3) Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens