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Literature summary for 1.2.4.2 extracted from

  • Mailloux, R.J.; Singh, R.; Brewer, G.; Auger, C.; Lemire, J.; Appanna, V.D.
    alpha-Ketoglutarate dehydrogenase and glutamate dehydrogenase work in tandem to modulate the antioxidant alpha-ketoglutarate during oxidative stress in Pseudomonas fluorescens (2009), J. Bacteriol., 191, 3804-3810.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information KGDH is sharply decreased in cells challenged with menadione, treatment of cellular extracts from the menadione-exposed cells with 5 mM dithiothreitol partially restores the activity of KGDH, KGDH levels are diminished when ammonium is utilized as the nitrogen source Pseudomonas fluorescens

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
strain ATCC 13525
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Pseudomonas fluorescens [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
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Synonyms

Synonyms Comment Organism
alpha-ketoglutarate dehydrogenase
-
Pseudomonas fluorescens
KG dehydrogenase
-
Pseudomonas fluorescens
KGDH
-
Pseudomonas fluorescens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Pseudomonas fluorescens